• The different serotypes A G have unique receptors to which

  2020-07-08

  

  The different serotypes (A-G) have unique receptors to which they bind to produce the toxic effect on the nerve cells. (Lance, 2004, Rosetto et al., 2014). Intracellularly, the endopeptidase activity of different serotypes of BoNT target selectively a unique group of proteins, the SNARE Senegenin mg

• Judging from the densitometric analysis of the Western blots

  2020-07-08

  

  Judging from the densitometric analysis of the Western blots, CYP2E1 protein was expressed, although at very low levels, by PT cells. This corresponds to previous observations [10], showing that CYP2E1 was expressed in the PT, although expression was higher in the distal tubule. Testosterone 6β-hyd

• Programmed cell death via apoptosis is associated

  2020-07-07

  

  Programmed cell death via apoptosis is associated with a series of morphological and biochemical characteristics, including cell shrinkage, the rapid increase of intracellular calcium, nuclear condensation, DNA fragmentation and the formation of apoptotic bodies. Known as a shared feature of most ap

• gpr109a inhibitor The present study also showed that EP defi

  2020-07-07

  

  The present study also showed that EP2 deficiency and EP4 antagonism significantly suppressed psoriatic gpr109a inhibitor in an imiquimod model. Notably, however, the combined EP2 deficiency and EP4 antagonism did not completely suppress ear swelling in this model, possibly because there is the IL-

• br Material and methods br Results br Discussion A

  2020-07-07

  

  Material and methods Results Discussion A. fumigatus utilizes several virulence factors that facilitate its establishment in human hosts. Among these factors, the best known are hydrolytic enzymes such as proteases and phospholipases, toxins, melanine and catalases that neutralize the react

• Heparin sodium br Materials and methods br Results br

  2020-07-07

  

  Materials and methods Results Discussion Ubiquitination is an important eukaryotic process that defines the fate of proteins and their functionality. It has multiple roles in cell survival, differentiation and development (Glickman and Ciechanover, 2002). Ubiquitination is usually known as

• It is reported that sympathetic nerve activity is increased

  2020-07-07

  

  It is reported that sympathetic nerve activity is increased in the SHR strain compared with that in the WKY strain (Judy and Farrell, 1979, Lundin et al., 1984, Sugimura et al., 2008) and NA content is increased in the CB of the New Zealand strain of hypertensive rat compared with that in normotensi

• Heparin br STAR Methods br Acknowledgments We thank Genevi v

  2020-07-07

  

  STAR★Methods Acknowledgments We thank Geneviève Almouzni, Sophie Polo, Ralph Scully, Wael Mansour, and Jeremy Stark for providing cell lines and Wolf Heyer, Haico van Attikum, Martijn Luijsterburg, and Brendan Price for helpful discussions. We thank Ratna Weimer, Bettina Basso, Christel Braun,

• During germ cell development in mouse de

  2020-07-07

  

  During germ cell development in mouse, de novo Dnmts regulate the genomic imprinting and silence of repeat elements. Dnmt3A methylated H19, Dlk1/Gtl2, and Sine B1, whereas Dnmt3B methylated microsatellite repeat elements, the two Dnmts co-methylatedRasgrf1, IAP, and Line1 repeat elements (Lucifero e

• br Materials and methods br Results

  2020-07-07

  

  Materials and methods Results Discussion Structural analysis of dnmt3 sequences of different ploidy fish cloned in this study showed high similarities to zebrafish sequences, which also contained a unique N-terminal motif and a calponin homology (CH) domain, a conserved proline-tryptophan-t

• Except for S adenosylmethionine SAM Fig sources of

  2020-07-07

  

  Except for S-adenosylmethionine (SAM, Fig. 1), sources of endogenous DNA alkylation are not well defined. Other possible sources include nitroso compounds related to the well known mutagen methylnitrosourea which are generated in vitro by nitrosation of cellular amines including amino acids, protein

• br Materials and methods br

  2020-07-07

  

  Materials and methods Results Discussion The studies reported here provide a more direct link between conformations of the glycine-rich region of DAPK and enzyme activity. As schematically illustrated in Fig. 3, the various conformations of DAPK with bound substrate or product can be consid

• First of all two assumptions just

  2020-07-06

  

  First of all, two assumptions just as in Ref. [30] are need to simplify the penetration process: (1) The crater phases is short and the 95 9 of EFP is consumed little; thus, the influence of crater on penetration can be ignored; (2) the initial stagnation radial pressure is equal to axial pressure,

• br Materials and methods BAECs

  2020-07-06

  

  Materials and methods BAECs (CAB30405, Toyobo Life Science, Osaka, Japan) were cultured in Dulbecco’s Modified Eagle Medium supplemented with 10% Fetal Bovine Serum (04-001-1A-US, Biological Industries, Kibbutz Beit Haemek, Israel) and 1% antibiotic-antifungal agent containing 10,000-μg/mL penici

• Aspergillus nigerA niger is another filamentous fungus

  2020-07-06

  

  Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi

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