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Having a better understanding of the inflammatory
2020-07-30
Having a better understanding of the inflammatory profiles is important for controlling the HFMD epidemic. There are no specific anti-viral therapy or multi-valent vaccines for HFMD (Takahashi et al., 2016, Zhu et al., 2014). Effectively identifying the HFMC cases and controlling the infection sourc
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glucose transporter Another major representative of the flav
2020-07-30
Another major representative of the flavonol myricetin also inhibited porcine CYP450 in a gender-related manner (Ekstrand et al., 2015). In the present study, myricetin did not affect CYP2E1 and inhibited CYP3A activity with a higher degree of inhibition in the pools from female individuals. CYP3A a
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br Introduction Chemokine receptors interact with a group
2020-07-30
Introduction Chemokine receptors interact with a group of peptide ligands of 8–10kDa and are indispensable for coordination of cell migration in diverse physiological processes such as development, angiogenesis, immune defence and neuroendocrine regulation. They belong to the largest rhodopsin fa
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S63845 When multiple concurrent users simultaneously make a
2020-07-30
When multiple concurrent users simultaneously make a request for GUI initialization, the server side is not able to respond to all users at the same time. Therefore, the “min” column in Fig. 17 gives the time taken for the first user to receive the response and complete the initialization process. T
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br Synthesis and mechanism of fluorescent DNA
2020-07-29
Synthesis and mechanism of fluorescent DNA-CuNMs Application of fluorescent DNA-CuNMs Summary and conclusions In summary, we introduce recent research progress in the synthesis and various applications of DNA-CuNMs. DNA-CuNMs with novel catalytic, electrical and optical properties can be ob
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Our findings suggest that the
2020-07-29
Our findings suggest that the Ligase IV/XRCC4 complex is formed in the Tunicamycin and subsequently controls the organization of a repair complex within the nucleus. Structural and biochemical studies have revealed that together with XRCC4, XLF forms long filamentous structures that are important f
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br Materials and methods br Results br Discussion
2020-07-29
Materials and methods Results Discussion The aim of the studies described in this paper was to identify determinants of the sensitivity of human colorectal cancer and NSCLC cell lines to the ZD2767 ADEPT system. In particular, the role of DNA–DNA interstrand cross-linking and TP53 status we
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From the theoretical point of
2020-07-29
From the theoretical point of view some rationalizations can be done if the symmetry considerations are included in the calculations. When only configurations are considered all systems of , and symmetry may be treated as a purely axial () ligand field [25], [26]. It means that in the present cas
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INDY Spearman s rank correlations between LDL cholesterol le
2020-07-29
Spearman\'s rank correlations between LDL cholesterol levels and cholesterol INDY markers are reported in Table 4. Sitosterol and stigmasterol in hyperabsorber families had a positive correlation with LDL cholesterol. However, no correlation was found for cholesterol absorption markers in non-hyper
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Southern blots and PCR analysis Genomic DNA was isolated fro
2020-07-29
Southern blots and PCR analysis. Genomic DNA was isolated from wild-type DT40 as well as from different clones of DT40YB-1b+/− using standard procedures [24]. DNA was then digested with different restriction enzymes, separated on an agarose gel, and subjected to a Southern blot with either the Chk-Y
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br DNA PK kinase activity As
2020-07-28
DNA-PK kinase activity As previously stated, DNA-PKcs recruitment to the DSB results in translocation of the Ku heterodimer inward on the dsDNA allowing DNA-PKcs to interact directly access DSB end, which results in activation of the catalytic activity of the enzyme [42], [43]. DNA-PKcs has no to
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Attempts to define the function of
2020-07-28
Attempts to define the function of individual DGK domains have resulted in inconclusive results. ATP binding motifs corresponding to the glycine-rich loops found in protein kinases (GxGxxG consensus sequence; Hanks et al., 1988, Hemmer et al., 1997) were identified in the first C1 and catalytic doma
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We also performed a correlation analysis
2020-07-28
We also performed a correlation analysis independent of annotated gene sets to identify potentially novel genes that are co-expressed with DHODH. Using the top 100 DHODH co-expressed genes in COAD, LGG, STAD, and PAAD diseases, we identified four common genes across all four diseases (Fig. 9). These
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br Wound healing is an evolutionarily conserved pathophysiol
2020-07-28
Wound healing is an evolutionarily conserved pathophysiological paradigm of fibrogenesis. The wound healing response to injury is known to trigger functional (i.e., proliferative) and phenotypic changes throughout the skin, with involvement of multiple cell types (e.g., fibroblasts, lymphocytes, e
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br CRM and malignancies Cell cycle regulators and various ot
2020-07-28
CRM1 and malignancies Cell cycle regulators and various other anti-neoplastic modulators of cell function that are abnormally exported from the nucleus into the cytoplasm of cancerous cells are, as a result, ancillary targets for CRM1 inhibition (Lapalombella et al., 2012, Inoue et al., 2013, Koj
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