• DGAT is specifically responsible for endogenous

  2021-05-12

  

  DGAT2 is specifically responsible for endogenous synthesis of TAGs which are then packed into cytosolic LDs in the cytosol for storage and luminal apolipoprotein B (apoB)-containing LDs in the ER lumen destined for VLDL secretion [122,127]. DGAT2 can also synthesize TAG using exogenous FAs and suppo

• The results of bisaryl ether linker study are shown

  2021-05-12

  

  The results of bisaryl ether linker study are shown in . It was found that the methylene linker () moderately improved the binding to the DP receptor. The increased binding potency was also diminished in the presence of plasma, possibly due to higher plasma protein binding. Other linkers, such as th

• Cancer has been linked to both

  2021-05-12

  

  Cancer has been linked to both genetic and epigenetic changes. Epigenetic modifications, mainly DNA methylation at CpG dinucleotides, affect the regulation of gene transcription without altering the gene's sequence. Short sequences rich in CpG dinucleotides (i.e., CpG islands) are often found in the

• The heterogeneity among studies that investigated

  2021-05-12

  

  The heterogeneity among studies that investigated the association of COMT Val158Met with alexithymia was also significant (Ham et al., 2005; Min et al., 2016; Swart et al., 2011; Zekioglu et al., 2014). The healthy status, drug effect, and other demographic variables also influenced one's ability of

• br Acknowledgements This work was supported

  2021-05-11

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• The selective estrogen receptor modulators SERMs are another

  2021-05-11

  

  The selective estrogen receptor modulators (SERMs) are another type of estrogen receptor ligands. The main difference between SERMs and xenoestrogens relies on the fact that SERMs present functional duality and are able to act both as agonists and antagonists of the estrogen receptors in different t

• Introduction Penetrator with Enhanced Lateral Effect PELE

  2021-05-11

  

  Introduction Penetrator with Enhanced Lateral Effect (PELE) is a kind of ammunition which consists of a low-density material as the filling and a high-density material as the jacket [1,2]. When PELE impact target, the jacket is radially accelerated, expanded and fractured because of distinctive lat

• br O GlcNAc transferase OGT belongs

  2021-05-11

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• Expression of both CH H and CYP B by lymphoid

  2021-05-11

  

  Expression of both CH25H and CYP7B1 by lymphoid stromal arginase inhibitors is required for the synthesis of 7α,25-OHC in lymphoid tissues and the correct positioning of B cells. Production of EBI2 ligand by hematopoietically derived cells appears limited [24] but may occur under some circumstances

• Several limitations of this study need to be acknowledged

  2021-05-11

  

  Several limitations of this study need to be acknowledged. First, although 200 patients were recruited into this study and completed assessments at baseline, only 89 patients completed the cognitive tests after 8weeks of treatment. The relatively long study period (8weeks) was the main reason for th

• However a two receptor model

  2021-05-11

  

  However, a two-receptor model presents a mystery of how MBns know whether they are receiving an acquisition or forgetting signal from the PPL1 DAns. The most attractive explanation for this is that the two receptors might have different signaling properties and mobilize distinct signaling cascades.

• Previous studies showed that many steroidogenic enzymes act

  2021-05-11

  

  Previous studies showed that many steroidogenic enzymes act when the enzyme binds to the cofactor first [30]. In the present study, we showed that HPTE inhibited both AKR1C14 and RDH2 in a mixed mode when cofactor was used. This indicates that HPTE interferes with cofactor-binding residues although

• The three dimensional crystal structure of

  2021-05-11

  

  The three-dimensional crystal structure of Ca2+ loaded CaM reveals a dumbbell-shaped molecule with two roughly globular lobes, the N- and C-terminal lobes linked by a long solvent-exposed helix, which has been shown by NMR to be non-helical in its central part and flexible in solution [13]. Each gl

• The isolation of a proteinaceous putative inhibitor

  2021-05-11

  

  The isolation of a proteinaceous putative inhibitor of cysteine proteases from the extracts of Y. enterocolitica and E. coli was performed by affinity chromatography on immobilized and inactivated papain (Fig. 7A). Instead of the column variant of this technique (Tsushima et al., 1992), we used a ba

• R co localizes Golgi marker GM Fig

  2021-05-11

  

  R co-localizes Golgi marker GM130 (Fig. 5). Our metabolic pulse-chase studies carried out in the presence of CSF-1 exposed the newly synthesized CSF-1R to its ligand, which promoted its rapid degradation. While this was clearly seen in control BMDMs, the mature band of CSF-1R remained intact for the

14747 records 644/984 page Previous Next First page 上5页 641642643644645 下5页 Last page