• Histamine H and H receptors are considered as low affinity

  2022-08-04

  

  Histamine H1 and H2 receptors are considered as low affinity receptors (pKi of 4.2 and 4.3 respectively), whereas histamine H3 and H4 receptors as a high affinity receptors (pKi of 8 and 8.2 respectively) (Schreeb et al., 2013). Therefore it might well be that other histamine receptors might be invo

• It is important to mention that the IC of cetirizine

  2022-08-04

  

  It is important to mention that the IC50 of cetirizine needed to achieve histamine H2 receptor desensitization was 0.43 µM or 170 ng/ml (Fig. 1B), becoming clinically relevant since pharmacokinetic studies after oral administration of the clinically used dose (10 mg/day) reported a maximal plasma co

• The neurotransmitter histamine plays a key role in

  2022-08-04

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in Cefotaxime sodium salt histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's di

• br Acknowledgments This research was funded by generous gran

  2022-08-04

  

  Acknowledgments This research was funded by generous grants from the Singapore National Medical Research Council (NMRC CBRG grant NMRC/CBRG12Nov114 (BD)). WJC is supported by NMRC Clinician Scientist Investigator award and partly supported by a Singapore Cancer Syndicate Grant, the National Resea

• br Author Contributions br Acknowledgments We thank Hiroyuki

  2022-08-04

  

  Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members

• BCA Protein Quantitation Kit sale The role of the cyclic

  2022-08-04

  

  The role of the cyclic AMP regulated exchange factor Epac1 is emerging in cancer (Almahariq et al., 2015, Banerjee and Cheng, 2015, Parnell et al., 2015, Parnell et al., 2015, Schmidt et al., 2013). Interestingly, in cancer cell migration, activation of Epac1 can be linked to activation of Rac. As s

• Glutathione transferases GST have been discovered in many ti

  2022-08-04

  

  Glutathione transferases (GST) have been discovered in many tissues including the cornea of humans and several other mammals (Awasthi et al., 1980, Bilgihan et al., 2003; Gondhowiardjo and van Haeringen, 1993; Saneto et al., 1982, Sastry et al., 1995, Singh et al., 1985, Watkins et al., 1991). To da

• GlxI is a member of the

  2022-08-04

  

  GlxI is a member of the βαβββ superfamily of proteins, consisting of fosfomycin resistance protein (FosA), methylmalonyl-CoA epimerase (MMCE), extradiol dioxygenase (DIOX), mitomycin C resistance protein (MRP) and bleomycin resistance protein (BRP) [29], [30], [31]. These proteins are believed to ha

• To evaluate SLC A abundance after

  2022-08-03

  

  To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 Gadodiamide were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose filter, and immunoblotted with an a

• Next we focused on B part

  2022-08-03

  

  Next, we focused on B-part, the phthalazine ring. While both nitrogen atoms of the phthalazine ring were found to be important (data not shown), replacing the benzene ring of the phthalazine part was attempted, and shows the results of the substituted pyridazine rings with bearing 2-methoxy benzene

• Since the isoflavone emerged as privileged scaffold in

  2022-08-03

  

  Since the isoflavone emerged as privileged scaffold in Hh inhibition, based on molecular modeling predictions and prior studies [17,22], here we designed a number of isoflavones able to interact preferentially with the Smo receptor or the Gli protein. Molecules were synthesized by means of a novel s

• Together our data are consistent with

  2022-08-03

  

  Together, our data are consistent with the idea that the antidepressant-like effect of a low dose of galanin administration in the DRN would be mediated by the activation of local GAL2. To support this hypothesis, we set an additional experiment to evaluate whether the antidepressant-like effect of

• Nano biocatalyst prepared by assembling an enzyme on

  2022-08-03

  

  Nano-biocatalyst, prepared by assembling an enzyme on nanomaterial (NM) carriers is an emerging innovation in the field of nanobiotechnology. Some of the advantages of using NM as supports in they have to say to conventional porous supports are effective enzyme loading due to large surface area with

• Caspase-9, human recombinant protein FPR ligands comprise s

  2022-08-03

  

  FPR ligands comprise structurally very diverse Caspase-9, human recombinant protein of compounds, ranging from naturally occurring peptides/proteins or “danger signals” such as PAMPs and DAMPs (see 1.1), respectively, to endogenous lipids and even various synthetic non-peptides, such as benzimidazo

• Polyunsaturated fatty acids PUFAs represent a class of

  2022-08-03

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic Caspase-8, human recombinant protein (DHA), eicosapentaenoic acid (EPA) and n-6

15109 records 414/1008 page Previous Next First page 上5页 411412413414415 下5页 Last page