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Whereas accurate measurement of glucagon in humans has been
2022-06-24
Whereas accurate measurement of glucagon in humans has been possible since the early 1950s proper measurements in rodents, have not. That said, plasma concentrations of glucagon have been reported in rodent studies [21] using C-terminal specific methods but what has been lacking is the secretory dyn
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The findings in this study may
2022-06-24
The findings in this study may represent an example of a more general phenomenon, namely that the exquisite specificity of the G protein-coupled receptors that mediate the physiological actions of the 5,8,11-Eicosatriynoic Acid family hormones in mammals may have arisen relatively late in evolution.
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br Contributions br Acknowledgements This research was suppo
2022-06-24
Contributions Acknowledgements This research was supported by Natural Sciences and Engineering Research Council (NSERC) Discovery grant No. 341538 and Ontario Graduate Scholarships to HM and VS. Introduction Sexual size dimorphism describes size difference between male and female individua
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br Conclusion and future directions GS is an important thera
2022-06-24
Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS
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But some experiments did not support the antinociceptive rol
2022-06-24
But some experiments did not support the antinociceptive role of GalR2 in peripheral locations beyond the DRG. The partial saphenous nerve ligation and the complete Freund's adjuvant model in the rats demonstrated that close intra-arterial infusion of galanin, but not galanin (2–11), reduced cooling
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gdc-0980 australia Similar to C lividipennis RDL
2022-06-24
Similar to C. lividipennis RDL (Jiang et al., 2015), we found that the intracellular loop variants of A. mellifera RDL had no effect on GABA EC50 (Table 1). Also, as with C. lividipennis, there was no significant difference in maximal GABA responses (Table 1). However, whereas the 31 amino acid inse
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In case where an extreme loop of up
2022-06-24
In case where an extreme loop (of up to 45 nt) is allowed, as in G3 + E3 + XX, however, a G3+GQ loop maximum of 3 was adequate to reach high J-statistic. It continued to increase only up to 6 as the loop maximum. (Fig. 1A) Hence we suggest using a G3+GQ loop maximum between 3 and 6 where an extreme
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Analysis of published albumin X ray structures had suggested
2022-06-24
Analysis of published albumin X-ray structures had suggested that an allosteric link may exist, but could not establish whether Zn2+ prevented FFA binding or vice versa. This question was answered through competition experiments monitored by isothermal titration calorimetry (ITC; Fig. 3) for BSA [55
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More recently Serna Marquez and colleagues investigated LA i
2022-06-24
More recently, Serna-Marquez and colleagues investigated LA-induced migration and invasion of MDA-MB-231 breast cancer cells. In this study, LA was shown to induce AKT-2 phosphorylation and cell invasion and migration in MDA cells. LA-induced cell migration was inhibited by siRNA that selectively ta
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br FREE FATTY ACID RECEPTOR GPR
2022-06-24
FREE FATTY ACID RECEPTOR 1 (GPR40) G-PROTEIN-COUPLED RECEPTOR 120 CONCLUSION Free fatty Kif15-IN-2 receptors whose natural ligands are identified as FFAs having various lengths have been reported. They act as novel nutrient sensing receptors independent of PPARs and FABPs, and they are know
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To meet the requirement of ferroptosis based
2022-06-24
To meet the requirement of ferroptosis-based therapy, a couple of small molecule drugs and nanomaterials were introduced to the design of ferroptosis inducers, separately. As we know, iron is a key regulator of ferroptosis. When small molecule drugs are employed to induce ferroptosis, the endogenous
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The suboptimal trypsin selectivity profile of DPC p
2022-06-24
The suboptimal trypsin selectivity profile of DPC423 prompted us to investigate additional P moieties for potency and selectivity. Glycinamide P () showed low nanomolar binding affinity against fXa which suggested that this P moiety sits deeper into the S pocket of fXa. To further elaborate on this
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Recent studies are beginning to explore this complex interpl
2022-06-24
Recent studies are beginning to explore this complex interplay of pathways. For example, intracellular trafficking of poly(lactic-co-glycolic acid)(PLGA) based nanoparticles was studied in detail using 30 different Rab proteins as markers for intracellular transport vesicles (involved in exocytosis,
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The progression of HIV varies from patient to
2022-06-24
The progression of HIV varies from patient to patient, with some who progress slowly and others who progress much faster. However, CD4+ and CD8+ cell counts are intimately linked in those that are able to suppress the HIV infection (Walker et al., 1986; Saez-Aninon et al., 2007). Depletion of these
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ensational new The CRY protein contains a conserved photolya
2022-06-23
The CRY1 protein contains a conserved photolyase homology region crucially involved in repression of CLOCK/BMAL1; a C-terminal helix also known as the predicted coiled coil (CC), which interacts with PER2 and FBXL3 in a mutually exclusive manner; and a C-terminal extension also referred to as the “t
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