• The hippocampus is the primary brain

  2025-02-10

  

  The hippocampus is the primary brain structure involved in learning and memory. The role of hippocampal synaptic plasticity in neurological processes in cognition and depression has been extensively demonstrated. Synaptophysin is a critical substance in synaptogenesis, which is necessary for learnin

• The following are the supplementary data

  2025-02-10

  

  The following are the supplementary data related to this article. Funding Work in Dr. Rosell's laboratory is partially supported by a grant from La Caixa Foundation, and an Instituto de Salud Carlos III grant (RESPONSE, PIE16/00011). Work in Dr. Cao's laboratory is partially supported by the Maj

• Aurora kinases were initially identified as protein

  2025-02-10

  

  Aurora kinases were initially identified as protein kinases essential for error-free chromosome segregation during mitosis and meiosis. Aurora A appears to control premetaphase events, such as bipolar spindle assembly 3, 4, with Aurora B and C directing metaphase and postmetaphase events, including

• Cx43 selective inhibitor Here we report discovery of

  2025-02-10

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of Cx43 selective inhibitor bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the in

• ATM is required for the proper

  2025-02-10

  

  ATM is required for the proper function of the DNA-repair pathway in response to bleomycin-induced DNA damage in mammalian cells [55], [56]. Recent reports suggest that ATM activation by double-strand breaks leads to the subsequent ATR activation [57], [58], [59]. The recruitment of ATR to double-st

• br Conclusions and future direction ER PgR breast cancers ha

  2025-02-10

  

  Conclusions and future direction ER(−)/PgR(+) breast cancers have a distinct clinical course, response to treatment, and molecular features when compared to other breast cancer types, however some of them are actually technical artifacts or consequences of too high definitions of positivity. Acco

• The compounds containing beryllium act

  2025-02-10

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be conotoxin []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentate Be

• p16 receptor Many coumarin derivatives can be

  2025-02-10

  

  Many coumarin derivatives can be found in nature. There are more than 1300 types of those purely derived from plants, and if synthetic products are included, their number is immeasurable. According to the earliest existing records extant, herbs containing Psoralen-type compounds, e.g., methoxsalen,

• Despite their different effects on cell survival

  2025-02-10

  

  Despite their different effects on cell survival, the functions of autophagy and apoptosis are not completely independent. Additionally, Cho et al. (2009) suggested that the mediation of caspase-3 links the apoptotic and autophagic signaling pathways. Consequently, to illuminate the correlation, exc

• rotenone As the experimental procedure used could

  2025-02-10

  

  As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA

• The AT hook motif is highly conserved in

  2025-02-08

  

  The AT-hook motif is highly conserved in evolution from bacteria to humans and is found in one or more copies in a large number of other, non-HMGA, proteins, many of which are transcription factors or are involved in chromatin remodeling [8]. For example, AT-hook peptide motifs are essential compone

• 6656 br Concluding Remarks and Future Perspectives Fluoresce

  2025-02-08

  

  Concluding Remarks and Future Perspectives Fluorescent 6656 have helped researchers to elucidate antibiotic MOA and off-target interactions, to screen for new antibiotics, to detect antibiotics in the environment, to track antibiotic uptake throughout cells and organisms, and to detect bacterial

• Flavopiridol kinase inhibitor Immunohistochemistry in tissue

  2025-02-08

  

  Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of Flavopiridol kinase inhibitor tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-activato

• N6-methyladenosine br Experimental Procedures br Acknowledgm

  2025-02-08

  

  Experimental Procedures Acknowledgments Introduction Cellular and molecular mechanisms underlying synaptic plasticity in the N6-methyladenosine are thought to be involved in memory acquisition. Synaptic plasticity is categorised into two main types, long-term depression (LTD) and long-term

• br Introduction The structural similarities

  2025-02-08

  

  Introduction The structural similarities between puromycin (1, Fig. 1) and the aminoacyl adenyl terminal of aminoacyl–tRNA allow it to terminate the protein synthesis process by causing premature release of a polypeptide from the ribosome [1], [2]. Tremendous progress in the study of puromycin an

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