• MafB a member of the Maf protein family is

  2024-11-29

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in Silodosin with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of

• There are essentially two screening strategies

  2024-11-28

  

  There are essentially two screening strategies to minimize the number of newborns recalled for additional testing without missing cases for most screening disorders. For hyperargininemia, one strategy uses Arg alone as the indicator of possible disease and the other uses Arg in combination with a ra

• Dopaminergic neurons are vulnerable to oxidative products

  2024-11-28

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial 5,7-Dichlorokynurenic acid are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cel

• br Materials and methods br Results br Discussion

  2024-11-28

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino ceramide kinase sequence identity among these species is not high (38–52%), our synteny analysis clear

• br HIF Blockade in AA Therapy In lieu of

  2024-11-28

  

  HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary

• br STAR Methods br Acknowledgments We

  2024-11-28

  

  STAR★Methods Acknowledgments We thank Simcere Pharmaceuticals, Nanjing, China, for providing a rabbit anti-VEGF neutralizing monoclonal antibody. We thank Dr. Schlisio in the Ludwig Institute for Cancer Research, Karolinska Institute, for assistance with hypoxia assay. Y.C.’s laboratory is sup

• Polycyclic aromatic hydrocarbons PAHs are

  2024-11-28

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, GLP-2 (rat) synthesis burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some P

• The enzyme mediated ATP sensing mechanism in zebrafish can

  2024-11-27

  

  The enzyme-mediated ATP-sensing mechanism in zebrafish can be compared with previous studies in other animal species reporting that enzymatic conversion of chemicals in the peripheral olfactory organ results in either “activation” or “inactivation” of odorants and pheromones. In male silkmoth, the a

• Systematic administration of ABT amino bromophenyl morpholin

  2024-11-27

  

  Systematic administration of ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl) pyrido[2,3-d] pyrimidine), a potent and selective non-nucleoside AK inhibitor, also generates analgesic effects in animal models of pain (Jarvis et al., 2000, Kowaluk et al., 2000, Suzuki et al., 2001), sug

• perindopril erbumine australia Casein accounts for of the to

  2024-11-27

  

  Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have

• br Materials and methods br Results br

  2024-11-27

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• br Conflicts of interest br Acknowledgments The authors ackn

  2024-11-27

  

  Conflicts of interest Acknowledgments The authors acknowledge National Institute for Medical Research Development (NIMAD) project no. 940943 and National Research Institute for Science Policy (NRISP) no. 1456 for financial support of this work. AM appreciates National Institute for Genetic Eng

• We showed that activation of the ATM ATR pathway leads

  2024-11-27

  

  We showed that activation of the ATM/ATR pathway leads to over-replication through suppression of CDK1 activity, consistent with previous findings that suppression of CDK1 activity is involved in the polyploidization of megakaryocyte and trophoblast cells [36], [37], [38], [39]. Suppression of CDK1

• br Conclusions and future direction ER PgR breast

  2024-11-27

  

  Conclusions and future direction ER(−)/PgR(+) breast cancers have a distinct clinical course, response to treatment, and molecular features when compared to other breast cancer types, however some of them are actually technical artifacts or consequences of too high definitions of positivity. Acco

• GABAB receptor is associated with brain and behavioral disea

  2024-11-27

  

  GABAB receptor is associated with osi sc 175 and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patien

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